Jane Esdale, in 1849, lost her daughter in May and her husband in December.
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Died the year preceding the 1850 Census: Mortality index
ESDALE ROBERT*MEIGS CO. OH 56 M Month =DEC Place of Birth: SL Cause of Death: PURPAL FVR Occupation: FARMER

1850 Census.
270 15 370 379 Esdale Jane 43 F 1600 Pa - - - -
270 16 370 379 Esdale Mary 21 F Ia - - - -
270 17 370 379 Esdale Rebecca 19 F Ia - X - -
270 18 370 379 Esdale Benjamin 15 M none Ia - X - -
270 19 370 379 Esdale Margaret 12 F Ohio - X - -

270 20 371 380 Esdale William 25 M farmer 300 Ia - - - -
270 21 371 380 Esdale Nancy 29 F Pa - - - -
270 22 371 380 Esdale Elizabeth C. 2 F Ohio - - - -
270 23 371 380 Esdale Mary I. 1 F Ohio - - - -

Family 384 nearby.
271 02 375 384 Stewart John S. 58 M farmer Md - - - -
271 03 375 384 Stewart Sarah 49 F Pa - - - -
271 04 375 384 Ollum Isaac 15 M farmer Ohio - X - -
271 05 375 384 Ollum Menerva 13 F Ohio - X - -
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1860 Cass Twp., Ohio Co., IN, Page 384, Listed as Asdale
14 14 Jane Asdale, 53, 800, 300, Pennsylvania
Margaret Asdale, 7, Indiana

18 18 Wm. Vanosdal age 7 is staying with neighbors

19 19 John Vanosdal, 39,
Sarah, 31 [Kittle]
Rachel, 9
Nathan, 5
William, 2
John, 1/2

Note: Thanks to:
http://familytreemaker.genealogy.com/users/r/a/m/Jo-A-Ramseyer/GENE8-0015.html
JOHN YAW VAN OSDOL Father: Nathan Allen, Grandfather: Johannis “John”, was born 26 November 1820 in Pa, and died 13 March 1902 in Ohio Co. He married SARAH KITTLE, November 1848 in Ohio Co, daughter of PHINEUS KITTLE and MARGARIT.